year 2021

Post-stroke treatment with K-134, a phosphodiesterase 3 inhibitor, improves stroke outcomes in the stroke-prone spontaneously hypertensive rat model – a comparative evaluation of antiplatelet drugs
Hideo Yoshida, Shinsuke Itoh, Farhana Ferdousi, Hiroko Isoda
Journal of Pharmacological Sciences.148(2):229-237.(2021)

Syntheses and aggregation properties of new squalene receptors bearing open chain ligands
Tran Ngoc Linh,Takashi Arimura, Kenichi Tominaga, Hideo Kigoshi, Hiroko Isoda
Supramolecular Chemistry.33(5):194-201.(2021)

DNA Microarray-Based Global Gene Expression Profiling in Human Amniotic Epithelial Cells Predicts the Potential of Microalgae-Derived Squalene for the Nervous System and Metabolic Health
Farhana Ferdousi, Kinji Furuya, Kazunori Sasaki, Yun-Wen Zheng, Tatsuya Oda, Hiroko Isoda
Biomedicines.10(1):48.(2021)

Essential Oil- loaded Nanoemulsion Lipidic-Phase Optimization and Modelling by Response Surface Methodology (RSM): Enhancement of Their Antimicrobial Potential and Bioavailability in Nanoscale Food Delivery System
Sana Yakoubi, Isao Kobayashi, Kunihiko Uemura, Mitsutoshi NAKAJIMA, Hiroko Isoda, Riadh Ksouri, Moufida Saidani-Tounsi,Marcos A Neves
Foods.10(12): 3149.(2021)

Effect of Citrulline and Leucine Intake with Exercises on Body Composition, Physical Activity, and Amino Acid Concentration in Older Women: A Randomized Double-Blind Placebo-Controlled Study
Mijin Kim, Hiroko Isoda,Tomohiro Okura
Foods.10(12):3117.(2021)

Heme oxygenase-1 induction by heat shock in rat hepatoma cell line is regulated by the coordinated function of HSF1, NRF2 and BACH1
Akagi R, Kubo T, Hatori Y, Miyamoto T, Inouye S.
J Biochem.170(4):501-510.(2021)

Predictive ability of current machine learning algorithms for type 2 diabetes mellitus: A meta-analysis.
Kodama S, Fujihara K, Horikawa C, Kitazawa M, Iwanaga M, Kato K, Watanabe K, Nakagawa Y, Matsuzaka T, Shimano H, Sone H.
J Diabetes Investig.13(5):900-908.(2021)

Combined effect of daily physical activity and social relationships on sleep disorder among older adults: cross-sectional and longitudinal study based on data from the Kasama study
Seol J, Lee J, Nagata K, Fujii Y, Joho K, Tateoka K, Inoue T, Liu J, Okura T.
BMC Geriatr.21(1):623.(2021)

The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis.
Sekiya M, Kainoh K, Sugasawa T, Yoshino R, Hirokawa T, Tokiwa H, Nakano S, Nagatoishi S, Tsumoto K, Takeuchi Y, Miyamoto T, Matsuzaka T, Shimano H.
Nat Commun.12(1):6315.(2021)

Luteolin modulates Neural Stem Cells Fate Determination: in vitro study on Human Neural stem cells, and in vivo study on LPS-induced depression mice model
Mariem Achour, Farhana Ferdousi, Kazunori Sasaki, Hiroko Isoda
Frontiers in Cell and Developmental Biology-Stem Cell Research.9:753279.(2021)

Albino mice with the point mutation at the tyrosinase locus show high cholesterol diet-induced NASH susceptibility
Kulathunga K, Wakimoto A, Hiraishi Y, Yadav MK, Gentleman K, Warabi E, Sakasai T, Miwa Y, Mizuno S, Takahashi S, Hamada M
Sci Rep.11(1):21827.(2021)

Antidepressant- and anxiolytic-like activities of Rosmarinus officinalis extract in rodent models: Involvement of oxytocinergic system
Kazunori Sasaki, Farhana Ferdousi, Satoshi Fukumitsu, Hidetoshi Kuwata, Hiroko Isoda
Biomedicine & Pharmacotherapy. 144:112291.(2021)

Formulation, physicochemical characterization, and anti- E. coli activity of food-grade nanoemulsions incorporating clove, cinnamon, and lavender essential oils
Hanen Falleha, Mariem Ben Jemaa, Marcos A.Neves, Hiroko Isoda, Mitsutoshi Nakajima, Riadh Ksouri
Food Chemistry.359:129963.(2021)

Relationships between Cognitive Function and Odor Identification, Balance Capability, and Muscle Strength in Middle-Aged Persons with and without Type 2 Diabetes
Midorikawa M, Suzuki H, Suzuki Y, Yamauchi K, Sato H, Nemoto K, Sugano Y, Iwasaki H, Sekiya M, Yatoh S, Yahagi N, Hada Y, Arai T, Shimano H.
J Diabetes Res.2021:9961612.(2021)

COVID-19 cynomolgus macaque model reflecting human COVID-19 pathological conditions
Urano E, Okamura T, Ono C, Ueno S, Nagata S, Kamada H, Higuchi M, Furukawa M, Kamitani W, Matsuura Y, Kawaoka Y, Yasutomi Y.
Proc Natl Acad Sci U S A.118(43):e2104847118.(2021)

Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle
Mizunoe Y, Kobayashi M, Saito H, Goto A, Migitaka R, Miura K, Okita N, Sudo Y, Tagawa R, Yoshida M, Umemori A, Nakagawa Y, Shimano H, Higami Y.
Exp Gerontol. 154:111519.(2021)

Altered microbiota by a high-fat diet accelerates lethal myeloid hematopoiesis associated with systemic SOCS3 deficiency
Cho K, Ushiki T, Ishiguro H, Tamura S, Araki M, Suwabe T, Katagiri T, Watanabe M, Fujimoto Y, Ohashi R, Ajioka Y, Shimizu I, Okuda S, Masuko M, Nakagawa Y, Hirai H, Alexander WS, Shimano H, Sone H.
iScience.24(10):103117.(2021)

CREBH Systemically Regulates Lipid Metabolism by Modulating and Integrating Cellular Functions
Nakagawa Y, Araki M, Han SI, Mizunoe Y, Shimano H.
Nutrients.13(9):3204.(2021)

Carrot Consumption Frequency Associated with Reduced BMI and Obesity through the SNP Intermediary rs4445711
Fujihara K, Nogawa S, Saito K, Horikawa C, Takeda Y, Cho K, Ishiguro H, Kodama S, Nakagawa Y, Matsuzaka T, Shimano H, Sone H.
Nutrients. 13(10):3478.(2021)

Template activating factor-I epigenetically regulates the TERT transcription in human cancer cells
Kato K, Kawaguchi A, Nagata K.
Scientific Reports.11(1):17726.(2021)

Prohydrojasmon Promotes the Accumulation of Phenolic Compounds in Red Leaf Lettuce
Shinya Takahashi, Yui Namioka, Haidar Rafid Azis, Tomoharu Sano, Mitsuko Aono, Masami Koshiyama, Hiroshi Fujisawa, Hiroko Isoda
Plants.10(9):1920.(2021)

Emulsifying Performance of Crude Surface-Active Extracts from Liquorice Root (Glycyrrhiza Glabra)
Noamane Taarji, Meryem Bouhoute, Youssef Chafai, Abdellatif Hafidi, Isao Kobayashi, Marcos A. Neves, Kenichi Tominaga, Hiroko Isoda, Mitsutoshi Nakajima
ACS Food Sci. Technol. 8:1472–1480.(2021)

Design of nanoemulgel using Argania spinosa microfibrillated cellulose and natural emulsifiers foreseeing melanogenesis enhancement
Meryem Bouhoute, Mitsutoshi Nakajima, Hiroko Isoda
CarbohydratePolymers.274:118632.(2021)

Highly susceptible SARS-CoV-2 model in CAG promoter-driven hACE2-transgenic mice
Asaka MN, Utsumi D, Kamada H, Nagata S, Nakachi Y, Yamaguchi T, Kawaoka Y, Kuba K, Yasutomi Y
JCI Insight.6(19):e152529.(2021)

Peppermint and Myrtle nanoemulsions: Formulation, stability, and antimicrobial activity
Hanen Falleh, Mariem Ben Jemaa, Marcos A. Neves, Hiroko Isoda, Mitsutoshi Nakajima, Riadh Ksouri
LWT – Food Science and Technology.152: 112377.(2021)

Preventive effect of a Kampo medicine, kososan, on recurrent depression in a mouse model of repeated social defeat stress
Naoki Ito, Kazunori Sasaki, Eiji Hirose, Takayuki Nagai, Hiroko Isoda, Hiroshi Odaguchi
Gene.806: 145920.(2021)

Maslinic Acid Attenuates Denervation-Induced Loss of Skeletal Muscle Mass and Strength
Yuki Yamauchi, Farhana Ferdousi, Satoshi Fukumitsu, Hiroko Isoda
Nutrients.13(9): 2950.(2021)

Tara (Caesalpinia spinosa L.) tannin promotes proliferation and expression of hair growth-associated markers in human follicular dermal papilla cells
Myra O. Villareal, Meriem Bejaoui, Thanyanan Chaochaiphat, Kozo Sato, Hiroko Isoda
Euro-Mediterranean Journal for Environmental Integration.6:68.(2021)

Elucidation of Melanogenesis-Associated Signaling Pathways Regulated by Argan Press Cake in B16 Melanoma Cells
Thouria Bourhim, Myra O. Villareal, Chemseddoha Gadhi, Hiroko Isoda
Nutrients.13(8):2697.(2021)

Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes
Lee S, Ishitsuka A, Kuroki T, Lin YH, Shibuya A, Hongu T, Funakoshi Y, Kanaho Y, Nagata K, Kawaguchi A.
JCI Insight.6(16):e139190.(2021)

Serum lactate dehydrogenase level as a possible predictor of treatment preference in psoriasis
Koguchi-Yoshioka H, Watanabe R, Matsumura Y, Ishitsuka Y, Inoue S, Furuta J, Nakamura Y, Okiyama N, Matsuzaka T, Shimano H, Fujisawa Y, Fujimoto M.
J Dermatol Sci.103(2):109-115.(2021)

Protocol for rapid manipulation of mitochondrial morphology in living cells using inducible counter mitochondrial morphology (iCMM)
Miyamoto T, Han SI, Shimano H.
STAR Protoc. 2(3):100721.(2021)

Prevalence of Germline Variants in a Large Cohort of Japanese Patients with Pheochromocytoma and/or Paraganglioma
Yonamine M, Wasano K, Aita Y, Sugasawa T, Takahashi K, Kawakami Y, Shimano H, Nishiyama H, Hara H, Naruse M, Okamoto T, Matsuda T, Kosugi S, Horiguchi K, Tanabe A, Watanabe A, Kimura N, Nakamura E, Sakurai A, Shiga K, Takekoshi K.
Cancers (Basel). 13(16):4014.(2021)

Rapid manipulation of mitochondrial morphology in a living cell with iCMM
Takafumi Miyamoto, Hideki Uosaki, Yuhei Mizunoe, Song-Iee Han, Satoi Goto, Daisuke Yamanaka, Masato Masuda, Yosuke Yoneyama, Hideki Nakamura, Naoko Hattori, Yoshinori Takeuchi, Hiroshi Ohno, Motohiro Sekiya, Takashi Matsuzaka, Fumihiko Hakuno, Shin-Ichiro Takahashi, Naoya Yahagi, Koichi Ito, Hitoshi Shimano
Cell Reports Methods.1(4):100052.(2021)

CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF2
Kainoh K, Takano R, Sekiya M, Saito K, Sugasawa T, Ma Y, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Takeuchi Y, Yahagi N, Suzuki H, Miyamoto T, Nakagawa Y, Matsuzaka T, Shimano H.
Biochem Biophys Res Commun. 562:146-153.(2021)

Spectral Clustering Joint Deep Embedding Learning by Autoencoder
Xiucai Ye, Chunhao Wang, Akira Imakura, Tetsuya Sakurai
Proceeding of the International Joint Conference on Neural Networks (IJCNN).1-7(2021)

Grape skin extract modulates neuronal stem cell proliferation and improves spatial learning in senescence-accelerated prone 8 mice
Kazunori Sasaki, Noelia Geribaldi-Doldan, Francis G Szele, Hiroko Isoda
Aging.13(14):18131-18149.(2021)

Argan (Argania Spinosa) press cake extract enhances cell proliferation and prevents oxidative stress and inflammation of human dermal papilla cells
Meriem Bejaoui, Noamane Taarji, Masako Saito, Mitsutoshi Nakajima, Hiroko Isoda
Journal of Dermatological Science. 103(1):33-40.(2021)

Green Solvent to Substitute Hexane for Bioactive Lipids Extraction from Black Cumin and Basil Seeds
Soumaya Bourgou, Iness Bettaieb Rebey, Sofiene Ben Kaab, Majdi Hammami, Sarra Dakhlaoui, Selmi Sawsen, Kamel Msaada, Hiroko Isoda, Riadh Ksouri, Marie-Laure Fauconnier
Foods. 10(7):1493.(2021)

Comprehensive transcriptome analysis of erythroid differentiation potential of olive leaf in haematopoietic stem cells
Shinji Kondo, Farhana Ferdousi, Ken Yamauchi, Sofya Suidasari, Miki Yokozawa, Mohamed Moncef Harrabi, Ken-ichi Tominaga, Hiroko Isoda
J Cell Mol Med. 25(15):7229-7243.(2021)

The evidence of a macrophage barrier in the xenotransplantation of human hematopoietic stem cells to severely immunodeficient rats
Kinji Furuya, Yun-Wen Zheng, Jian-Yun Ge, Ludi Zhang, Tomoaki Furuta, Chen Liang, Haruna Abe, Hiroya Yagi, Hiromi Hamada, Hiroko Isoda, Lijian Hui, Nobuhiro Ohkohchi, Tatsuya Oda
Xenotransplantation.28(4):e12702.(2021)

Differences in the Effects of Anthocyanin Supplementation on Glucose and Lipid Metabolism According to the Structure of the Main Anthocyanin: A Meta-Analysis of Randomized Controlled Trials
Risa Araki, Akira Yada, Hirotsugu Ueda, Kenichi Tominaga, Hiroko Isoda
Nutrients.13(6): 2003.(2021)

Evaluation of the anti-stress effects of five Tunisian aromatic and medicinal plants in vitro
Mahmoud Ben Othman, Mohamed Neffati, Hiroko Isoda
Journal of Herbal Medicine.27: 100238.(2021)

Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling
Nakagawa Y, Kumagai K, Han SI, Mizunoe Y, Araki M, Mizuno S, Ohno H, Matsuo K, Yamada Y, Kim JD, Miyamoto T, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Takahashi S, Sone H, Shimano H.
FASEB J.35(6):e21663.(2021)

Homozygous Familial Hypercholesterolemia
Nohara A, Tada H, Ogura M, Okazaki S, Ono K, Shimano H, Daida H, Dobashi K, Hayashi T, Hori M, Matsuki K, Minamino T, Yokoyama S, Harada-Shiba M.
J Atheroscler Thromb. 28(7):665-678.(2021)

Macrophages rely on extracellular serine to suppress aberrant cytokine production
Kurita K, Ohta H, Shirakawa I, Tanaka M, Kitaura Y, Iwasaki Y, Matsuzaka T, Shimano H, Aoe S, Arima H, Ogawa Y, Ito A, Suganami T.
Sci Rep.11(1):11137.(2021)

The effects of geographic region and cultivar on oxidative stability and elemental analysis of Tunisian extra virgin olive oil
Ahmed Wali, Fadwa Damak, Kiyokazu Kawada, Hiroko Isoda, Kenji Tamura, Mohamed Ksibi
Eur Food Res Technol.247: 1401–1409.(2021)

Two Types of PPARγ Ligands Identified in the Extract of Artemisia campestris
Tokio Hasegawa, Mayo Osaka, Yusaku Miyamae, Katsutoshi Nishino, Hiroko Isoda, Kiyokazu Kawada, Mohamed Neffati, Kazuhiro Irie, Masaya Nagao
Chemistry.3(2):647-657.(2021)

Stability characteristics of O/W emulsions prepared using purified glycyrrhizin or a non-purified glycyrrhizin-rich extract from liquorice root (Glycyrrhiza glabra)
Noamane Taarji, Meryem Bouhoute, Hakiki Melanie, Abdellatif Hafidi, Isao Kobayashi, Marcos Neves, Kenichi Tominaga, Hiroko Isoda, Mitsutoshi Nakajima
Colloids and Surfaces A: Physicochemical and Engineering Aspects.614:126006.(2021)

Human Amniotic Epithelial Cells as a Tool to Investigate the Effects of Cyanidin 3‐O‐Glucoside on Cell Differentiation
Shinya Takahashi, Farhana Ferdousi, Yun‐Wen Zheng, Tatsuya Oda, Hiroko Isoda
Int. J. Mol. Sci.22(7):3768.(2021)

Emulsion Formation and Stabilizing Properties of Olive Oil Cake Crude Extracts
Firdaous Fainassi, Noamane Taarji, Fatiha Benkhalti, Abdellatif Hafidi, Marcos A. Neves, Hiroko Isoda, Mitsutoshi Nakajima
Processes.9(4):633.(2021)

Utilization of a novel Sendai virus vector in ex vivo gene therapy for hemophilia A
Yamaki Y, Fukushima T, Yoshida N, Nishimura K, Fukuda A, Hisatake K, Aso M, Sakasai T, Kijima-Tanaka J, Miwa Y, Nakanishi M, Sumazaki R, Takada H
Int J Hematol.113(4):493-499.(2021)

Generation of two ISL1-tdTomato reporter human induced pluripotent stem cell lines using CRISPR-Cas9 genome editing
Tsukamoto S, Nakade K, Wakabayashi T, Nakashima K, Takami M, Hemmi Y, Kuramochi Y, Shimizu T, Arai Y, Matsuo-Takasaki M, Noguchi M, Nakamura Y, Miwa Y, Hayashi Y
Stem Cell Res.53:102363.(2021)

Potent mouse monoclonal antibodies that block SARS-CoV-2 infection
Guo Y, Kawaguchi A, Takeshita M, Sekiya T, Hirohama M, Yamashita A, Siomi H, Murano K.
Journal of Biological Chemistry.296:100346.(2021)

Genome-wide screening of upstream transcription factors using an expression library
Yahagi N, Takeuchi Y.
F1000Res.10:51.(2021)

Budget impact analysis reveals walk-in fingertip HbA1c testing in community pharmacies could provide a significant long-term reduction in public expenditure
Shono A, Kondo M, Hoshi SL, Okubo R, Yahagi N.
Res Social Adm Pharm.17(2):368-371.(2021)

Severity of hypertension as a predictor of initiation of dialysis among study participants with and without diabetes mellitus
Osawa T, Fujihara K, Harada Yamada M, Yamamoto M, Kitazawa M, Matsubayashi Y, Iwanaga M, Yamada T, Seida H, Kodama S, Nakagawa Y, Shimano H, Sone H.
J Investig Med.69(3):724-729.(2021)

Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry)
Ueki K, Tanizawa Y, Nakamura J, Yamada Y, Inagaki N, Watada H, Shimomura I, Nishimura R, Miyoshi H, Abiko A, Katagiri H, Hayashi M, Shimada A, Naruse K, Fujimoto S, Fujiwara M, Shikata K, Okada Y, Araki E, Yamazaki T, Kadowaki T; J-BRAND Registry Group.
BMJ Open Diabetes Res Care.9(1): e001787. (2021)

Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan
Tateishi R, Matsumura T, Okanoue T, Shima T, Uchino K, Fujiwara N, Senokuchi T, Kon K, Sasako T, Taniai M, Kawaguchi T, Inoue H, Watada H, Kubota N, Shimano H, Kaneko S, Hashimoto E, Watanabe S, Shiota G, Ueki K, Kashiwabara K, Matsuyama Y, Tanaka H, Kasuga M, Araki E, Koike K; LUCID study investigators.
J Gastroenterol.56(3):261-273. (2021)

Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non-alcoholic steatohepatitis model
Shimizu Y, Tamura T, Kemmochi A, Owada Y, Ozawa Y, Hisakura K, Matsuzaka T,
Shimano H, Nakano N, Sakashita S, Oda T, Ohkohchi N.
J Gastroenterol Hepatol. 36(3):800-810.(2021)