year 2022

ELOVL6 deficiency aggravates allergic airway inflammation through the ceramide-S1P pathway in mice.
Yoshida K, Morishima Y, Ano S, Sakurai H, Kuramoto K, Tsunoda Y, Yazaki K, Nakajima M, Sherpa MT, Matsuyama M, Kiwamoto T, Matsuno Y, Ishii Y, Hayashi A, Matsuzaka T, Shimano H, Hizawa N.
J Allergy Clin Immunol.151(4):1067-1080.e9.(2022)

DC-COX: Data collaboration Cox proportional hazards model for privacy-preserving survival analysis on multiple parties
Akira Imakura, Ryoya Tsunoda, Rina Kagawa, Kunihiro Yamagata, Tetsuya Sakurai
Journal of Biomedical Informatics.137:104264.(2022)

Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation
Kazuhiro Aonuma, DongZhu Xu, Nobuyuki Murakoshi, Kazuko Tajiri, Yuta Okabe, Zixun Yuan, Siqi Li, Yoshiko Murakata, Kenichi Tominaga, Akihiko Nogami, Kazutaka Aonuma, Masaki Ieda, Hiroko Isoda
Clin Sci (Lond).136(24):1831-1849.(2022)

Impact of exercising alone and exercising with others on the risk of cognitive impairment among older Japanese adults
K. Nagata, K. Tsunoda, Y. Fujii, T. Jindo, T. Okura
Archives of Gerontology and Geriatrics.107:104908.(2022)

A case of NASH with genetic predisposition successfully treated with an SGLT2 inhibitor: a possible involvement of mitochondrial dysfunction
Rikako Nakajima, Motohiro Sekiya, Yasuhisa Furuta, Takafumi Miyamoto, Masashi Sato, Kuniaki Fukuda, Keiichiro Hattori, Yasuhito Suehara, Mamiko Sakata-Yanagimoto, Shigeru Chiba, Yuka Okajima, Takashi Matsuzaka, Satoru Takase, Mikio Takanashi, Hiroaki Okazaki, Yusuke Takashima, Mikiko Yuhara, Yuta Mitani, Nako Matsumoto, Yuki Murayama, Mariko Ohyama Osawa, Nami Ohuchi, Daichi Yamazaki, Sayuri Mori, Yoko Sugano, Yoshinori Osaki, Hitoshi Iwasaki, Hiroaki Suzuki, Hitoshi Shimano
Endocrinol Diabetes Metab Case Rep.2022(22):0368.(2022)

Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease
Masaya Araki, Yoshimi Nakagawa, Hodaka Saito, Yasunari Yamada, Song-Iee Han, Yuhei Mizunoe, Hiroshi Ohno, Takafumi Miyamoto, Motohiro Sekiya, Takashi Matsuzaka, Hirohito Sone, Hitoshi Shimano
Am J Physiol Gastrointest Liver Physiol.323(6):G627-G639.(2022)

TMPRSS2 gene polymorphism common in East Asians confers decreased COVID-19 susceptibility
Sekiya T, Ogura Y, Kai H, Kawaguchi A, Okawa S, Hirohama M, Kuroki T, Morii W, Hara A, Hiramatsu Y, Hitomi S, Kawakami Y, Arakawa Y, Maruo K, Chiba S, Suzuki H, Kojima H, Tachikawa H, Yamagata K.
Front Microbiol.13:943877.(2022)

Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice
Nagata K, Utsumi D, Asaka MN, Maeda R, Shirakawa K, Kazuma Y, Nomura R, Horisawa Y, Yanagida Y, Kawai Y, Sato K, Yamaoka Y, Miyakawa K, Ryo A, Yasutomi Y, Imura A, Takaori-Kondo A.
Commun Med.2(1):152.(2022)

Physicochemical Stability Enhancement of β-carotene-rich O/W Nanoemulsions using a New Natural Emulsifier Developed from Pistacia lentiscus Fruit Residue
Firas Feki, Noamane Taarji, Sekove Vodo, Mohamed Chamkha, Zouhaier Bouallagui, Mitsutoshi Nakajima, Hiroko Isoda, Marcos A. Neves, Sami Sayadi
Food Biophysics.18:249–261. (2022)

L-Asparaginase-Induced Continuous Hyperglycemia With Type 1 Diabetes-Related Antibodies and HLA Genotypes: A Case Study
Yasuhisa Furuta, Shigeru Yatoh, Hitoshi Iwasaki, Yoko Sugano, Motohiro Sekiya, Hiroaki Suzuki, Hitoshi Shimano
Cureus.14(10):e30067.(2022)

Knowledge distillation-based privacy-preserving data analysis
Dong Huang, Xiucai Ye, Tetsuya Sakurai
Proceedings of the Conference on Research in Adaptive and Convergent Systems:15-20.(2022)

ToxinMI: improving peptide toxicity prediction by fusing multimodal information based on mutual information
Lesong Wei, Xiucai Ye, Tetsuya Sakurai
Proceedings of the Conference on Research in Adaptive and Convergent Systems:77-82.(2022)

Effects of Branched-Chain Amino Acids on Skeletal Muscle, Glycemic Control, and Neuropsychological Performance in Elderly Persons with Type 2 Diabetes Mellitus: An Exploratory Randomized Controlled Trial
Takaaki Matsuda, Hiroaki Suzuki, Yoko Sugano, Yasuhiro Suzuki, Daisuke Yamanaka, Risa Araki, Naoya Yahagi, Motohiro Sekiya, Yasushi Kawakami, Yoshinori Osaki, Hitoshi Iwasaki, Koichi Hashimoto, Shin-Ichiro Takahashi, Yasushi Hada, Hitoshi Shimano
Nutrients.14(19):3917.(2022)

Bidirectional associations between physical activity and sleep in older adults: a multilevel analysis using polysomnography
J. Seol, J. Lee, I. Park, K. Tokuyama, S. Fukusumi, T. Kokubo, M. Yanagisawa, T. Okura
Scientific Reports.12(1):15399.(2022)

微細藻類の生理活性作用
礒田博子; 佐々木一憲; 高橋 真哉
FRAGRANCE JOURNAL 50 (9) 10-15. (2022).

A case of early-onset diabetes with impaired insulin secretion carrying a PAX6 gene Gln135* mutation
Motohiro Sekiya, Mikiko Yuhara, Yuki Murayama, Mariko Ohyama Osawa, Rikako Nakajima, Nami Ohuchi, Nako Matsumoto, Daichi Yamazaki, Sayuri Mori, Takaaki Matsuda, Yoko Sugano, Yoshinori Osaki, Hitoshi Iwasaki, Hiroaki Suzuki, Hitoshi Shimano
Endocrinol Diabetes Metab Case Rep.2022(1):271.(2022)

Divide-and-conquer based large-scale spectral clustering
Hongmin Li, Xiucai Ye, Akira Imakura, Tetsuya Sakurai
Neurocomputing.501:664-678.(2022)

Ensemble Learning for Cluster Number Detection Based on Shared Nearest Neighbor Graph and Spectral Clustering
Weihang Zhang, Xiucai Ye, Testuya Sakurai
Proceeding of International Joint Conference on Neural Networks (IJCNN):1–8.(2022)

Missing value imputation with low-rank matrix completion in single-cell RNA-seq data by considering cell heterogeneity
Meng Huang, Xiucai Ye, Hongmin Li, Tetsuya Sakurai
Frontiers in Genetics.13:952649.(2022)

Exploratory analysis using machine learning of predictive factors for falls in type 2 diabetes
Yasuhiro Suzuki, Hiroaki Suzuki, Tatsuya Ishikawa, Yasunori Yamada, Shigeru Yatoh, Yoko Sugano, Hitoshi Iwasaki, Motohiro Sekiya, Naoya Yahagi, Yasushi Hada, Hitoshi Shimano
Sci Rep.12(1):11965.(2022)

ELOVL5-mediated fatty acid elongation promotes cellular proliferation and invasion in renal cell carcinoma
Satoshi Nitta, Shuya Kandori, Ken Tanaka, Shotaro Sakka, Masanobu Siga, Yoshiyuki Nagumo, Hiromitsu Negoro, Takahiro Kojima, Bryan J. Mathis, Toru Shimazui, Takafumi Miyamoto, Takashi Matsuzaka, Hitoshi Shimano, Hiroyuki Nishiyama
Cancer Sci.113(8):2738-2752.(2022)

Multi-View Federated Learning with Data Collaboration
Yitao Yang, Xiucai Ye, Tetsuya Sakurai
Proceeding of the International Conference on Machine Learning and Computing. (ICMLC):178-183.(2022)

Multiview network embedding for drug-target interactions prediction by consistent and complementary information preserving
Yifan Shang, Xiucai Ye, Yasunori Futamura, Liang Yu, Tetsuya Sakurai
Briefings in Bioinformatics.23(3):bbac059.(2022)

Elucidation of the Potential Hair Growth-Promoting Effect of Botryococcus terribilis, Its Novel Compound Methylated-Meijicoccene, and C32 Botryococcene on Cultured Hair Follicle Dermal Papilla Cells Using DNA Microarray Gene Expression Analysis
Aprill Kee Oliva, Meriem Bejaoui, Atsushi Hirano, Takashi Arimura, Tran Ngoc Linh, Eriko Uchiage, Sachiko Nukaga, Kenichi Tominaga, Hiroyuki Nozaki, Hiroko Isoda
Biomedicines.10(5):1186.(2022)

ARHGAP1 Transported with Influenza Viral Genome Ensures Integrity of Viral Particle Surface through Efficient Budozone Formation
Kuroki T, Hatta T, Natsume T, Sakai N, Yagi A, Kato K, Nagata K, Kawaguchi A.
mBio.13(3):e0072122.(2022)

Sequential reinforcement active feature learning for gene signature identification in renal cell carcinoma
Meng Huang, Xiucai Ye, Akira Imakura, Tetsuya Sakurai
Journal of Biomedical Informatics.128:104049.(2022)

Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice
Yuka Okajima Takashi Matsuzaka, Shun Miyazaki, Kaori Motomura, Hiroshi Ohno, Rahul Sharma, Takuya Shimura, Nurani Istiqamah, Song-Iee Han, Yuhei Mizunoe, Yoshinori Osaki, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Hirohito Sone, Takafumi Miyamoto, Yuichi Aita, Yoshinori Takeuchi, Motohiro Sekiya, Naoya Yahagi, Yoshimi Nakagawa, Tsutomu Tomita, Hitoshi Shimano 
Biochim Biophys Acta Mol Basis Dis.1868(4):166339.(2022)

ToxIBTL: prediction of peptide toxicity based on information bottleneck and transfer learning
Lesong Wei, Xiucai Ye, Tetsuya Sakurai, Zengchao Mu, Leyi Wei
Bioinformatics.38(6):1514-1524.(2022)

NerLTR-DTA: drug–target binding affinity prediction based on neighbor relationship and learning to rank
Xiaoqing Ru, Xiucai Ye, Tetsuya Sakurai, Quan Zou
Bioinformatics.38(7):1964-1971.(2022)

Dietary consumption of desert olive tree pearls reduces brain Aβ content and improves learning and memory ability in aged mice
Kazunori Sasaki, Hiroko Isoda
Journal of Functional Foods.91(17):105021.(2022)

Seasonal Changes in the Plant Growth-Inhibitory Effects of Rosemary Leaves on Lettuce Seedlings
Kwame Sarpong Appiah, Richard Ansong Omari, Siaw Onwona-Agyeman, Christiana Adukwei Amoatey, John Ofosu-Anim, Abderrazak Smaoui, Abdelkarim Ben Arfa, Yoko Suzuki, Yosei Oikawa, Shin Okazaki, Keisuke Katsura, Hiroko Isoda, Kiyokazu Kawada,Yoshiharu Fujii
Plants.11(5):673.(2022)

Physicochemical stability and in-vitro bioaccessibility of concentrated γ-Oryzanol nanodispersions fabricated by solvent displacement method
Noamane Taarji, Meryem Bouhoute, Isao Kobayashi, Kenichi Tominaga, Hiroko Isoda, Mitsutoshi Nakajima
Food Chemistry.382:132300.(2022)

DAJIN enables multiplex genotyping to simultaneously validate intended and unintended target genome editing outcomes
Kuno A, Ikeda Y, Ayabe S, Kato K, Sakamoto K, Suzuki SR, Morimoto K, Wakimoto A, Mikami N, Ishida M, Iki N, Hamada Y, Takemura M, Daitoku Y, Tanimoto Y, Dinh TTH, Murata K, Hamada M, Muratani M, Yoshiki A, Sugiyama F, Takahashi S, Mizuno S.
PLoS Biol.20(1):e3001507.(2022)

Effects of Isorhamnetin on Diabetes and Its Associated Complications: A Review of In Vitro and In Vivo Studies and a Post Hoc Transcriptome Analysis of Involved Molecular Pathways
Feten Zar Kala, Mondher Boulaaba, Farhana Ferdousi, Hiroko Isoda
Int. J. Mol. Sci. 23(2):704.(2022)

ELOVL2 promotes cancer progression by inhibiting cell apoptosis in renal cell carcinoma
Tanaka K, Kandori S, Sakka S, Nitta S, Tanuma K, Shiga M, Nagumo Y, Negoro H, Kojima T, Mathis BJ, Shimazui T, Watanabe M, Sato TA, Miyamoto T, Matsuzaka T, Shimano H, Nishiyama H.
Oncol Rep.47(2):23.(2022)

CREBH regulation of lipid metabolism through multifaceted functions that improve arteriosclerosis
Nakagawa Y, Matsuzaka T, Shimano H.
J Diabetes Investig.13(7):1129-1131.(2022)

Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques
Nagatake T, Kishino S, Urano E, Murakami H, Kitamura N, Konishi K, Ohno H, Tiwari P, Morimoto S, Node E, Adachi J, Abe Y, Isoyama J, Sawane K, Honda T, Inoue A, Uwamizu A, Matsuzaka T, Miyamoto Y, Hirata SI, Saika A, Shibata Y, Hosomi K, Matsunaga A, Shimano H, Arita M, Aoki J, Oka M, Matsutani A, Tomonaga T, Kabashima K, Miyachi M, Yasutomi Y, Ogawa J, Kunisawa J.
Mucosal Immunol.15(2):289-300.(2022)

Preparation and characterization of concentrated γ-Oryzanol nanodispersions by solvent displacement method: Effect of processing conditions on nanoparticles formation
Noamane Taarji, Meryem Bouhoute, Isao Kobayashi, Kenichi Tominaga, Hiroko Isoda, Mitsutoshi Nakajima
Food Hydrocolloids.123:107161.(2022)

Different impacts of metabolic profiles on future risk of cardiovascular disease between diabetes with and without established cardiovascular disease: the Japan diabetes complication and its prevention prospective study 7 (JDCP study 7).
Takahara M, Katakami N, Hayashino Y, Nishimura R, Suzuki H, Shimano H, Yoshioka N, Tajima N, Yamasaki Y.
Acta Diabetol.59(1):57-65.(2022)