year 2023

Hematinic potential of olive leaf extract: Evidence from an in vivo study in mice and a pilot study in healthy human volunteers
Shinji Kondo, Farhana Ferdousi, Jinchang Zhao, Sofya Suidasari, Miki Yokozawa, Ken Yamauchi, Ken-ichi Tominaga, Hiroko Isoda
Nutrients.15(19):4095.(2023)

Transcriptomics and Biochemical Evidence of Trigonelline Ameliorating Learning and Memory Decline in the Senescence-Accelerated Mouse Prone 8 (SAMP8) Model by Suppressing Proinflammatory Cytokines and Elevating Neurotransmitter Release
Sharmin Aktar, Farhana Ferdousi, Shinji Kondo, Tamami Kagawa, Hiroko Isoda
GeroScience:023-00919.(2023)

GR-KLF15 pathway controls hepatic lipogenesis during fasting
Takeuchi Y, Murayama Y, Aita Y, Mehrazad Saber Z, Karkoutly S, Tao D, Katabami K, Ye C, Shikama A, Masuda Y, Izumida Y, Miyamoto T, Matsuzaka T, Kawakami Y, Shimano H, Yahagi N.
FEBS J:16957.(2023)

Investigation into Molecular Brain Aging in Senescence-Accelerated Mouse (SAM) Model Employing Whole Transcriptomic Analysis in Search of Potential Molecular Targets for Therapeutic Interventions
Michitaka Fujiwara, Farhana Ferdousi, and Hiroko Isoda
Int. J. Mol. Sci.24(18):13867.(2023)

Multi-omics clustering for cancer subtyping based on latent subspace learning
Xiucai Ye, Yifan Shang, Tianyi Shi, Weihang Zhang, Tetsuya Sakurai
Computers in Biology and Medicine.164:107223.(2023)

Self-stabilizing performance of γ-oryzanol in oil-in-water emulsions and solid dispersions
Noamane Taarji, Meryem Bouhoute, Lorena de Oliveira Felipe, Mansour Sobeh, Isao Kobayashi, Marcos A. Neves, Kenichi Tominaga, Hiroko Isoda, Mitsutoshi Nakajima
Heliyon.9(9): e19677.(2023)

Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function
Sekiya M, Ma Y, Kainoh K, Saito K, Yamazaki D, Tsuyuzaki T, Chen W, Adi Putri PIP, Ohno H Miyamoto T, Takeuchi Y, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Yahagi N, Suzuki H, Motomura K, Matsuzaka T, Murata K, Mizuno S, Takahashi S, Shimano H.
Cell Rep.42(8):112914.(2023)

Multi-view Network Embedding with Structure and Semantic Contrastive Learning
Yifan Shang, Xiucai Ye, Tetsuya Sakurai
Proceedings of the IEEE International Conference on Multimedia and Expo (ICME):870-875.(2023)

Effects of Desert Olive Tree Pearls Containing High Hydroxytyrosol Concentrations on the Cognitive Functions of Middle-Aged and Older Adults
Jieun Yoon, Kazunori Sasaki, Iku Nishimura, Haruna Hashimoto, Tomohiro Okura, Hiroko Isoda
Nutrients.15(14):3234.(2023)

Data collaboration analysis in predicting diabetes from a small amount of health checkup data
Go Uchitachimoto, Noriyoshi Sukegawa, Masayuki Kojima, Rina Kagawa, Takashi Oyama, Yukihiko Okada, Akira Imakura, Tetsuya Sakurai
Scientific Reports.13(1):11820.(2023)

A Rare Olive Compound Oleacein Improves Lipid and Glucose Metabolism, and Inflammatory Functions: A Comprehensive Whole-Genome Transcriptomics Analysis in Adipocytes Differentiated from Healthy and Diabetic Adipose Stem Cells
Rui Wang, Munkhzul Ganbold, Farhana Ferdousi, Kenichi Tominaga, Hiroko Isoda
Int. J. Mol. Sci.24(13):10419.(2023)

Common and Unique Features Learning in Multi-view Network Embedding
Yifan Shang, Xiucai Ye, Tetsuya Sakurai
Proceeding of International Joint Conference on Neural Networks (IJCNN):1-8.（2023）

Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity
Saito K, Sekiya M, Kainoh K, Yoshino R, Hayashi A, Han SI, Araki M, Ohno H, Takeuchi Y, Tsuyuzaki T, Yamazaki D, Wanpei C, Hada L, Watanabe S, Paramita Adi Putri PI, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Yahagi N, Suzuki H, Miyamoto T, Matsuzaka T, Shimano H.
J Biol Chem.299(7):104890.(2023)

Molecular language models: RNNs or transformer?
Yangyang Chen, Zixu Wang, Xiangxiang Zeng, Yayang Li, Pengyong Li, Xiucai Ye, Tetsuya Sakurai.
Briefings in Functional Genomics.22(4):392-400.(2023)

Non-readily identifiable data collaboration analysis for multiple datasets including personal information
Akira Imakura, Tetsuya Sakurai, Yukihiko Okada, Tomoya Fujii, Teppei Sakamoto, Hiroyuki Abe
Information Fusion.98:101826.(2023)

Efficacy and Safety of Bladder Preservation Therapy in Combination with Atezolizumab and Radiation Therapy (BPT-ART) for Invasive Bladder Cancer: Interim Analysis from a Multicenter, Open-label, Prospective Phase 2 Trial
Kimura T, Ishikawa H, Nagumo Y, Sekino Y, Kageyama Y, Ushijima H, Kawai T, Yamashita H, Azuma H, Nihei K, Takemura M, Hashimoto K, Maruo K, Tsuzuki T, Nishiyama H
Int J Radiat Oncol Biol Phys.117(3):644-651.

Another use of SMOTE for interpretable data collaboration analysis
Akira Imakura, Masateru Kihira, Yukihiko Okada, Tetsuya Sakurai
Expert Systems with Applications.228:120385.(2023)

Solid acid-catalyzed one-step synthesis of oleacein from oleuropein
Yasuhiro Shimamoto, Tadahiro Fujitani, Eriko Uchiage, Hiroko Isoda, Ken-Ichi Tominaga
Scientific Reports.13(1):8275.(2023)

A Descriptive Whole-Genome Transcriptomics Study in a Stem Cell-Based Tool Predicts Multiple Tissue-Specific Beneficial Potential and Molecular Targets of Carnosic Acid
Farhana Ferdousi, Kazunori Sasaki, Satoshi Fukumitsu, Hidetoshi Kuwata, Mitsutoshi Nakajima, Hiroko Isoda
Int. J. Mol. Sci.24(9):8077.(2023)

Effects of home-based manual dexterity training on cognitive function among older adults: a randomized controlled trial
Jaehoon Seol, Namhoon Lim, Koki Nagata, Tomohiro Okura
European Review of Aging and Physical Activity.20(1):9.(2023)

Botryococcus terribilis Ethanol Extract Exerts Anti-inflammatory Effects on Murine RAW264 Cells
S Takahashi, F Ferdousi, S Yamamoto, A Hirano, S Nukaga, H Nozaki, H Isoda
Int. J. Mol. Sci.24(7):6666.(2023)

Network meta-analysis of glucose-lowering drug treatment regimens with the potential risk of hypoglycemia in patients with type 2 diabetes mellitus in terms of glycemic control and severe hypoglycemia
Kodama S, Fujihara K, Ishiguro H, Matsubayashi Y, Kitazawa M, Iwanaga M, Yamada T, Kato K Nakagawa Y, Tanaka S, Shimano H, Sone H.
J Investig Med.71(4):400-410.(2023)

Large Maf transcription factor family is a major regulator of fast type IIb myofiber determination
Sadaki S, Fujita R, Hayashi T, Nakamura A, Okamura Y, Fuseya S, Hamada M, Warabi E, Kuno A, Ishii A, Muratani M, Okada R, Shiba D, Kudo T, Takeda S, Takahashi S.
Cell Rep.42(4):112289.(2023)

Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2
Fujino M, Morito N, Hayashi T, Ojima M, Ishibashi S, Kuno A, Koshiba S, Yamagata K, Takahashi S.
JCI Insight.8(6):e163306.(2023)

Effect of Alkali Metal Cations on the Unilamellar Vesicle of a Squalene Bearing 18-Crown-6
Tran Ngoc Linh, Takashi Arimura, Ken-Ichi Tominaga, Hiroko Isoda, Masato Kawasaki, Naruhiko Adachi
ACS Omega.8(12):11583-11587.(2023)

Takotsubo cardiomyopathy with left ventricle thrombus caused by subacute thyroiditis
Yamazaki D, Osaki Y, Suzuki H, Shimano H.
BMJ Case Rep.16(3):e250540.(2023)

The fatty acid elongase Elovl6is crucial for hematopoietic stem cell engraftment and leukemia propagation
Kiyoki Y, Kato T, Kito S, Matsuzaka T, Morioka S, Sasaki J, Makishima K, Sakamoto T, Nishikii H, Obara N, Sakata-Yanagimoto M, Sasaki T, Shimano H, Chiba S.
Leukemia.37(4):910-913.(2023)

Deep generative model for drug design from protein target sequence
Yangyang Chen, Zixu Wang, Lei Wang, Jianmin Wang, Pengyong Li, Dongsheng Cao, Xiangxiang Zeng, Xiucai Ye, Tetsuya Sakurai
Journal of Cheminformatics.15(1):38.(2023)

Interactive gene identification for cancer subtyping based on multi-omics clustering
Xiucai Ye, Tianyi Shi, Yaxuan Cui, Tetsuya Sakurai
Methods.211:61-67.(2023)

MafB Maintains β-Cell Identity under MafA-Deficient Conditions
Deng Z, Kuno A, Ojima M, Takahashi S.
Mol Cell Biol.42(8):e0054121.(2022)

New balance capability index as a screening tool for mild cognitive impairment
Suzuki Y, Tsubaki T, Nakaya K, Kondo G, Takeuchi Y, Aita Y, Murayama Y, Shikama A, MasudaY, Suzuki H, Kawakami Y, Shimano H, Arai T, Hada Y, Yahagi N.
BMC Geriatr.23(1):74.(2023)

Distortion-free PCA on sample space for highly variable gene detection from single-cell RNA-seq data
Momo Matsuda, Yasunori Futamura, Xiucai Ye, Tetsuya Sakurai
Frontiers in Computer Science.17(1):171310.(2023)

Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis
Nurani Istiqamah, Takashi Matsuzaka, Momo Shimizu, Kaori Motomura, Hiroshi Ohno, Shiho Hasebe, Rahul Sharma, Yuka Okajima, Erika Matsuda, Song-Iee Han, Yuhei Mizunoe, Yoshinori Osaki, Yuichi Aita, Hiroaki Suzuki, Hirohito Sone, Yoshinori Takeuchi, Motohiro Sekiya, Naoya Yahagi, Yoshimi Nakagawa, Hitoshi Shimano
BBA Advances.3:100078.(2023)

Glucocorticoids coordinate the bladder peripheral clock and diurnal micturition pattern in mice
Chihara I, Negoro H, Kono J, Nagumo Y, Tsuchiya H, Kojo K, Shiga M, Tanaka K, Kandori S, Mathis BJ, Nishiyama H.
Commun Biol. 6(1):81.(2023)

Empagliflozin in Patients with Chronic Kidney Disease
The EMPA-KIDNEY Collaborative Group; Herrington WG, Staplin N, Wanner C, Green JB, Hauske SJ, Emberson JR, Preiss D, Judge P, Mayne KJ, Ng SYA, Sammons E, Zhu D, Hill M, Stevens W, Wallendszus K, Brenner S, Cheung AK, Liu ZH, Li J, Hooi LS, Liu W, Kadowaki T, Nangaku M, Levin A, Cherney D, Maggioni AP, Pontremoli R, Deo R, Goto S, Rossello X, Tuttle KR, Steubl D, Petrini M, Massey D, Eilbracht J, Brueckmann M, Landray MJ, Baigent C, Haynes R.
N Engl J Med.388(2):117-127.(2023)

Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway
Fatma Hadrich, Asma Mahmoudi, Mohamed Chamkha, Hiroko Isoda, Sami Sayadi
Oxid Med Cell Longev.2023:6828230.(2023)